GrippeCanadaV3, Main, Exploration, bibRecord, 000650

Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.

Identifieur interne : 000650 ( Main/Exploration ); précédent : 000649; suivant : 000651

Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.

Auteurs : Danuta M. Skowronski [Canada] ; Gaston De Serres ; Natasha S. Crowcroft ; Naveed Z. Janjua ; Nicole Boulianne ; Travis S. Hottes ; Laura C. Rosella ; James A. Dickinson ; Rodica Gilca ; Pam Sethi ; Najwa Ouhoummane ; Donald J. Willison ; Isabelle Rouleau ; Martin Petric ; Kevin Fonseca ; Steven J. Drews ; Anuradha Rebbapragada ; Hugues Charest ; Marie-Eve Hamelin ; Guy Boivin ; Jennifer L. Gardy ; Yan Li ; Trijntje L. Kwindt ; David M. Patrick ; Robert C. Brunham

Source :

PLoS medicine [ 1549-1676 ] ; 2010.

RBID : pubmed:20386731

Descripteurs français

KwdFr :
- Canada (épidémiologie), Flambées de maladies, Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Observation, Sous-type H1N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (effets indésirables).
MESH :
- effets indésirables : Vaccins antigrippaux.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Canada, Grippe humaine.
- Flambées de maladies, Humains, Observation.
Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Canada (epidemiology), Disease Outbreaks, Humans, Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza Vaccines (adverse effects), Influenza, Human (epidemiology), Influenza, Human (virology), Observation.
MESH :
- chemical , adverse effects : Influenza Vaccines.
- geographic , epidemiology : Canada.
- epidemiology : Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Disease Outbreaks, Humans, Observation.

Abstract

BACKGROUND

In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.

METHODS AND FINDINGS

STUDIES INCLUDED

(1) test-negative case-control design based on Canada's sentinel vaccine effectiveness monitoring system in British Columbia, Alberta, Ontario, and Quebec; (2) conventional case-control design using population controls in Quebec; (3) test-negative case-control design in Ontario; and (4) prospective household transmission (cohort) study in Quebec. Logistic regression was used to estimate odds ratios for TIV effect on community- or hospital-based laboratory-confirmed seasonal or pH1N1 influenza cases compared to controls with restriction, stratification, and adjustment for covariates including combinations of age, sex, comorbidity, timeliness of medical visit, prior physician visits, and/or health care worker (HCW) status. For the prospective study risk ratios were computed. Based on the sentinel study of 672 cases and 857 controls, 2008-09 TIV was associated with statistically significant protection against seasonal influenza (odds ratio 0.44, 95% CI 0.33-0.59). In contrast, estimates from the sentinel and three other observational studies, involving a total of 1,226 laboratory-confirmed pH1N1 cases and 1,505 controls, indicated that prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009, with estimated risk or odds ratios ranging from 1.4 to 2.5. Risk of pH1N1 hospitalization was not further increased among vaccinated people when comparing hospitalized to community cases.

CONCLUSIONS

Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada. The occurrence of bias (selection, information) or confounding cannot be ruled out. Further experimental and epidemiological assessment is warranted. Possible biological mechanisms and immunoepidemiologic implications are considered.

DOI: 10.1371/journal.pmed.1000258
PubMed: 20386731

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000652
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Le document en format XML

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<term>Disease Outbreaks</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza Vaccines (adverse effects)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
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<term>Flambées de maladies</term>
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<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
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<term>Vaccins antigrippaux (effets indésirables)</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS AND FINDINGS</b>
</p>
<p></p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDIES INCLUDED</b>
</p>
<p>(1) test-negative case-control design based on Canada's sentinel vaccine effectiveness monitoring system in British Columbia, Alberta, Ontario, and Quebec; (2) conventional case-control design using population controls in Quebec; (3) test-negative case-control design in Ontario; and (4) prospective household transmission (cohort) study in Quebec. Logistic regression was used to estimate odds ratios for TIV effect on community- or hospital-based laboratory-confirmed seasonal or pH1N1 influenza cases compared to controls with restriction, stratification, and adjustment for covariates including combinations of age, sex, comorbidity, timeliness of medical visit, prior physician visits, and/or health care worker (HCW) status. For the prospective study risk ratios were computed. Based on the sentinel study of 672 cases and 857 controls, 2008-09 TIV was associated with statistically significant protection against seasonal influenza (odds ratio 0.44, 95% CI 0.33-0.59). In contrast, estimates from the sentinel and three other observational studies, involving a total of 1,226 laboratory-confirmed pH1N1 cases and 1,505 controls, indicated that prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009, with estimated risk or odds ratios ranging from 1.4 to 2.5. Risk of pH1N1 hospitalization was not further increased among vaccinated people when comparing hospitalized to community cases.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada. The occurrence of bias (selection, information) or confounding cannot be ruled out. Further experimental and epidemiological assessment is warranted. Possible biological mechanisms and immunoepidemiologic implications are considered.</p>
</div>
</front>
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<ArticleTitle>Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.</AbstractText>
<AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS"></AbstractText>
<AbstractText Label="STUDIES INCLUDED" NlmCategory="METHODS">(1) test-negative case-control design based on Canada's sentinel vaccine effectiveness monitoring system in British Columbia, Alberta, Ontario, and Quebec; (2) conventional case-control design using population controls in Quebec; (3) test-negative case-control design in Ontario; and (4) prospective household transmission (cohort) study in Quebec. Logistic regression was used to estimate odds ratios for TIV effect on community- or hospital-based laboratory-confirmed seasonal or pH1N1 influenza cases compared to controls with restriction, stratification, and adjustment for covariates including combinations of age, sex, comorbidity, timeliness of medical visit, prior physician visits, and/or health care worker (HCW) status. For the prospective study risk ratios were computed. Based on the sentinel study of 672 cases and 857 controls, 2008-09 TIV was associated with statistically significant protection against seasonal influenza (odds ratio 0.44, 95% CI 0.33-0.59). In contrast, estimates from the sentinel and three other observational studies, involving a total of 1,226 laboratory-confirmed pH1N1 cases and 1,505 controls, indicated that prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009, with estimated risk or odds ratios ranging from 1.4 to 2.5. Risk of pH1N1 hospitalization was not further increased among vaccinated people when comparing hospitalized to community cases.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada. The occurrence of bias (selection, information) or confounding cannot be ruled out. Further experimental and epidemiological assessment is warranted. Possible biological mechanisms and immunoepidemiologic implications are considered.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Skowronski</LastName>
<ForeName>Danuta M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control (BCCDC), Vancouver, British Columbia, Canada. danuta.skowronski@bccdc.ca</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>De Serres</LastName>
<ForeName>Gaston</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Crowcroft</LastName>
<ForeName>Natasha S</ForeName>
<Initials>NS</Initials>
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<Author ValidYN="Y"><LastName>Janjua</LastName>
<ForeName>Naveed Z</ForeName>
<Initials>NZ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Boulianne</LastName>
<ForeName>Nicole</ForeName>
<Initials>N</Initials>
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<Author ValidYN="Y"><LastName>Hottes</LastName>
<ForeName>Travis S</ForeName>
<Initials>TS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rosella</LastName>
<ForeName>Laura C</ForeName>
<Initials>LC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dickinson</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gilca</LastName>
<ForeName>Rodica</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sethi</LastName>
<ForeName>Pam</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ouhoummane</LastName>
<ForeName>Najwa</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Willison</LastName>
<ForeName>Donald J</ForeName>
<Initials>DJ</Initials>
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<Author ValidYN="Y"><LastName>Rouleau</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
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<ForeName>Martin</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Fonseca</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Drews</LastName>
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<Initials>SJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rebbapragada</LastName>
<ForeName>Anuradha</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Charest</LastName>
<ForeName>Hugues</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hamelin</LastName>
<ForeName>Marie-Eve</ForeName>
<Initials>ME</Initials>
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   |clé=     pubmed:20386731
   |texte=   Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.
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Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.

Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.

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